Interferon Resistance of Hepatitis C Virus Genotype 1b: Relationship to Nonstructural 5A Gene Quasispecies Mutations
نویسندگان
چکیده
منابع مشابه
Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations.
A 40-amino-acid sequence located in the nonstructural 5A (NS5A) protein of hepatitis C virus genotype 1b (HCV-1b) was recently suggested to be the interferon sensitivity-determining region (ISDR), because HCV-1b strains with an ISDR amino acid sequence identical to that of the prototype strain HCV-J were found to be resistant to alpha interferon (IFN-alpha) whereas strains with amino acid subst...
متن کاملInterferon Resistance of Hepatitis C Virus Genotypes 1a/1b: Relationship to Structural E2 Gene Quasispecies Mutations
Hepatitis C virus (HCV) envelope glycoprotein-2 (E2) inhibits the interferon (IFN)–induced, double –stranded RNA activated protein kinase (PKR) via PKR eukaryotic initiation factor-2α phosphorylation homology domain (PePHD). Present study examined the genetic variability of the PePHD in patients receiving interferon therapy. The PePHD region from HCV genotype 1a/1b infected patients receiving I...
متن کاملinterferon resistance of hepatitis c virus genotypes 1a/1b: relationship to structural e2 gene quasispecies mutations
hepatitis c virus (hcv) envelope glycoprotein-2 (e2) inhibits the interferon (ifn)–induced, double –stranded rna activated protein kinase (pkr) via pkr eukaryotic initiation factor-2α phosphorylation homology domain (pephd). present study examined the genetic variability of the pephd in patients receiving interferon therapy. the pephd region from hcv genotype 1a/1b infected patients receiving i...
متن کاملThe nonstructural 5A protein of hepatitis C virus genotype 1b does not contain an interferon sensitivity-determining region.
BACKGROUND The nonstructural (NS) 5A protein of hepatitis C virus (HCV) has been suggested to contain an interferon (IFN) sensitivity-determining region (ISDR). METHODS We studied whether the degree of viral decline on day 1 is associated with differences in NS5A amino acid sequences among patients receiving IFN- alpha. RESULTS Phylogenetic analyses of the full-length protein and of functio...
متن کاملEvaluation of Interferon Resistance in Newly Established Genotype 1b Hepatitis C Virus Cell Culture System
BACKGROUND AND AIMS The hepatitis C virus (HCV) genotype 1b is known to exhibit treatment resistance with respect to interferon (IFN) therapy. Substitution of amino acids 70 and 91 in the core region of the 1b genotype is a significant predictor of liver carcinogenesis and poor response to pegylated-IFN-α and ribavirin therapy. However, the molecular mechanism has not yet been clearly elucidate...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1998
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.72.4.2795-2805.1998